Mammalian cell culture has long been an invaluable tool in cell biology, drug discovery and regenerative medicine. When cell culture techniques were first developed, 3-Dimensional (3D) systems were utilized. That rapidly changed due to cost and efficiency concerns resulting in cell culture now being performed with adherent cells grown on flat and rigid two-dimensional (2D) substrates including polystyrene and glass. Advances in our understanding of cell physiology and failures in clinical trials have provided the impetus to move away from 2D systems and back to a more in-vivo-like 3D environment. The advances of these new technologies and screening methodologies have allowed scientists to assess more realistic functional capabilities of cells. The following course will focus on the cellular microenvironment and its importance when developing and screening cell-based assays using primary, stem cell and immortalized cultures in 3D systems.
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Austin Mogen, Ph.D. Austin Mogen, Ph.D., is a Field Application Scientist at Corning Life Sciences. He received his doctorate from the University of Florida before working as a Senior Scientist of upstream process development and supervisor for manufacturing of viral vectors. In these positions he focused on bioprocess development, closed system solutions for cell culture scale-up and production of viral vectors for cell and gene therapy. Mogen works extensively with academic researchers and process development groups, optimizing cell culture assays and cellular scale-up conditions. In addition, he focuses on collaborations utilizing high-end 3D technology products such as the Corning spheroid microplates, transwell inserts and extracellular matrices to provide more in vivo models for biological research and therapeutic response. |
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Joe Clayton, Ph.D. Joe Clayton, Ph.D., is a Principal Scientist at BioTek Instruments, Inc. He received his Ph.D. in Molecular, Cell and Biomedical Sciences from the University of Vermont and his M.S. in Healthcare Research from The Dartmouth Institute. Clayton’s primary role at BioTek is developing and optimizing kinetic live cell imaging applications, utilizing advanced 2D and 3D systems. |
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